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In cases where the neutral placeholder results in an overestimate in HLA binding potential, it is preferable to use the low-affinity placeholder Z. In the EpiMatrix scoring system, for each allele and binding position, amino acid Z imputes the value of the lowest affinity natural amino acid

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Type 2 diabetes is treated with the antihyperglycemic medication metformin HCl

Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation